ea0020oc3.2 | Reproduction/Stress/Endocrine Disruptors | ECE2009
Kevenaar Marlies E
, Themmen Axel PN
, van Kerkwijk Anke J
, Valkenburg Olivier
, Uitterlinden Andre G
, de Jong Frank H
, Laven Joop SE
, Visser Jenny A
Polycystic ovary syndrome (PCOS) is characterized by anovulation, hyperandrogenemia, and polycystic ovaries. Although the etiology of PCOS is poorly understood, the common denominator is a disturbance in the selection of the dominant follicle. TGFβ family members, such as anti-Müllerian hormone (AMH) and bone morphogenetic proteins (BMPs), suppress FSH sensitivity. Therefore their signaling pathway may contribute to the aberrant follicle development in PCOS women. We...